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Target intelligence / Profile preview
Cyclic GMP Phosphodiesterase 2 (PDE2)
- Target
- PDE2
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
Cyclic GMP phosphodiesterase 2 (PDE2) is an enzyme that degrades the secondary messengers cyclic AMP (cAMP) and cyclic GMP (cGMP). It hydrolyzes both cAMP and cGMP, with its activity toward cAMP enhanced in the presence of cGMP. It plays a critical role in regulating intracellular concentrations of cyclic nucleotides and modulating cross-talk between the NO/cGMP pathway and β-adrenoceptor/cAMP signaling pathways. Modulation or inhibition of PDE2 has been explored for potential therapeutic benefits in cardiovascular diseases.
02
Mechanism of action
Hydrolyzes cAMP and cGMP, with activity toward cAMP enhanced by cGMP; Modulation/Inhibition of PDE2 alters cyclic nucleotide signaling
03
Biological functions
Signal transductionRegulation of intracellular cyclic nucleotide concentrationsModulation of cAMP/cGMP signaling pathwaysRegulation of mitochondrial respirationRegulation of apoptosis
04
Disease associations
Cardiovascular diseaseHeart failureHypertension
05
Safety considerations
Potential for off-target effects due to broad expression and interaction with multiple signaling pathways.Development of selective inhibitors is a challenge.
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