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Target intelligence / Profile preview
Cyclic GMP phosphodiesterase 5 (PDE5)
- Target
- PDE5
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
Cyclic GMP phosphodiesterase 5 (PDE5) is an enzyme that hydrolyzes cyclic guanosine monophosphate (cGMP), a key intracellular second messenger. It is highly expressed in the corpus cavernosum, retina, and vascular smooth muscle cells. PDE5 regulates vasodilation and smooth muscle relaxation by controlling cGMP levels. Inhibition of PDE5 is the mechanism of action for drugs used to treat erectile dysfunction and pulmonary arterial hypertension.
- Other names
- cGMP phosphodiesterase 5PDE VPDE5A
02
Mechanism of action
Selective inhibition of PDE5, leading to increased intracellular cGMP levels.
03
Biological functions
Hydrolysis of cGMPRegulation of cGMP levelsVasodilation regulationSmooth muscle relaxation regulationSignal transduction
04
Disease associations
Erectile dysfunctionPulmonary arterial hypertensionBenign prostatic hyperplasiaCardiovascular disease
05
Safety considerations
HypotensionVisual disturbancesPriapismDrug interactions (nitrates)
06
Interacting drugs
Sildenafil
3 more in the full profile.
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