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Target intelligence / Profile preview
Cyclic nucleotide-gated cation channel alpha 3 subunit (CNGA3)
- Target
- CNGA3
- Molecular classification
- Ion channel, Cyclic nucleotide-gated channel
01
Overview
The CNGA3 protein is an alpha subunit of cyclic nucleotide-gated (CNG) cation channels found in cone photoreceptors. These channels are crucial for color vision, allowing the influx of cations in the dark and closing upon light exposure during phototransduction. Mutations in CNGA3 cause several inherited retinal disorders, including achromatopsia and cone dystrophy.
- Other names
- ACHM2CCNC1CCNCaCCNCalphaCNCG3CNG3CNGA3_HUMANCone photoreceptor cGMP-gated channel alpha subunit
02
Mechanism of action
Modulation of ion flow in response to cGMP levels
03
Biological functions
Sensory transductionIon transportPhototransduction
04
Disease associations
AchromatopsiaColor blindnessCone dystrophyMacular dystrophy
05
Safety considerations
Potential for off-target effects on other ion channelsChallenges in achieving selective targeting of cone photoreceptors
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