Cyclic nucleotide-gated cation channel beta 3

Cyclic nucleotide-gated cation channel beta 3 (CNGB3) is a protein subunit that forms part of the cone photoreceptor cyclic nucleotide-gated (CNG) channels. These channels are essential for visual signal transduction in response to light. CNGB3 contributes unique structural features influencing ion permeation. Its primary role is mediating photoresponses under bright light conditions. Mutations in CNGB3 cause autosomal recessive achromatopsia, characterized by loss of color discrimination, highlighting its critical role in human cone cells for daylight/color vision.

Other names

ACHM1Cyclic nucleotide gated channel beta 3cyclic nucleotide gated channel subunit beta 3

Direct gating by cyclic nucleotides leading to ion channel opening and depolarization.