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Target intelligence / Profile preview
Cyclic nucleotide-gated cation channel beta 3 subunit (CNGB3)
- Target
- CNGB3
- Molecular classification
- Ion channel, Receptor
01
Overview
The cyclic nucleotide-gated cation channel beta 3 subunit (CNGB3) is a crucial component of the cone photoreceptor cyclic nucleotide-gated (CNG) ion channel. This channel is essential for color vision and visual acuity. CNGB3 forms a heterotetrameric complex with CNGA3 subunits, modulating channel function and contributing to the phototransduction process in cone cells. Mutations in CNGB3 are associated with inherited retinal diseases such as achromatopsia and progressive cone dystrophy.
- Other names
- ACHM1ACHM3Cone photoreceptor cGMP-gated channel subunit betaCyclic nucleotide-gated cation channel modulatory subunitCNG channel beta–3
02
Biological functions
Signal transductionVisual signal transduction
03
Disease associations
AchromatopsiaProgressive cone dystrophyJuvenile macular degenerationStargardt disease
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