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Target intelligence / Profile preview
Cyclic nucleotide-gated channel alpha 1
- Molecular classification
- Ion channel
01
Overview
Cyclic nucleotide-gated channel alpha 1 (CNGA1) is a pore-forming subunit of the rod photoreceptor cGMP-gated cation channel, crucial for visual phototransduction under low-light conditions. It mediates light-induced changes in membrane potential within rod photoreceptors by regulating the flow of Na⁺ and Ca²⁺ ions in response to cGMP levels. Mutations are associated with retinitis pigmentosa.
- Other names
- CNCGCNCG1CNG-1CNG1RCNC1RCNCaRCNCalphaRP49
02
Biological functions
Visual phototransductionCalcium ion transportSodium ion transport
03
Disease associations
Retinitis pigmentosa
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