Target intelligence / Profile preview

Cyclic nucleotide-gated channel alpha 1

Molecular classification: Ion channel

Overview

Cyclic nucleotide-gated channel alpha 1 (CNGA1) is a pore-forming subunit of the rod photoreceptor cGMP-gated cation channel, crucial for visual phototransduction under low-light conditions. It mediates light-induced changes in membrane potential within rod photoreceptors by regulating the flow of Na⁺ and Ca²⁺ ions in response to cGMP levels. Mutations are associated with retinitis pigmentosa.

Other names: CNCGCNCG1CNG-1CNG1RCNC1RCNCaRCNCalphaRP49

Biological functions

Visual phototransductionCalcium ion transportSodium ion transport

Disease associations

Retinitis pigmentosa

Beyond the preview

Go deeper on Cyclic nucleotide-gated channel alpha 1.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Cyclic nucleotide-gated channel alpha 1.

Explore the full profile