Target intelligence / Profile preview

Cyclic Nucleotide-Gated Channel Subunit Alpha 2 (HCN2)

Target: HCN2
Molecular classification: Ion channel, Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channel

Overview

HCN2 is a membrane protein that forms an ion channel permeable to sodium (Na⁺) and potassium (K⁺) ions, activated by hyperpolarization and modulated by cAMP binding. It generates the "funny" current (I_f), crucial for pacemaker activity in the heart and regulates neuronal excitability in the brain. It is implicated in cardiac arrhythmias and neuropathic pain.

Mechanism of action

Blockade of HCN2 channels

Biological functions

Pacemaking activityRegulation of neuronal excitability

Disease associations

Cardiac arrhythmiaChronic pain syndromesNeuropathic pain

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