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Target intelligence / Profile preview
Cyclin-A2 (CycA2)
- Target
- CycA2
- Molecular classification
- Cyclin
01
Overview
Cyclin-A2 is an essential regulator at multiple checkpoints within the mammalian somatic cell cycle. By activating specific kinases at precise times, it ensures orderly progression through DNA synthesis into mitosis while also playing emerging roles outside canonical cell division—including modulation of cellular architecture relevant for invasion/metastasis. Its dysregulation marks potential oncogenic transformation points across diverse cancer types.
- Other names
- CCNA2Cyclin A2Cyclin A
02
Mechanism of action
CDK1/CDK2 activator; promotes cell cycle progression
03
Biological functions
Cell cycleRegulation of G1/S transitionRegulation of G2/M transitionDNA synthesisCentrosome duplicationCytoskeletal dynamicsRegulation of RhoA activity
04
Disease associations
Cancer
05
Safety considerations
Dysregulation promotes uncontrolled cell proliferation
06
Biomarkers
CCNA2 overexpression as a biomarker for cancer
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