Cyclin and CBS domain divalent metal cation transport mediator 1 (CNNM1)

Cyclin and CBS domain divalent metal cation transport mediator 1 (CNNM1) is a member of the CNNM/ACDP (Ancient conserved domain protein) family, predominantly functioning as a divalent cation (notably magnesium) transporter or regulator within cells[1][2][4][5]. CNNM1 contains four main domains: an extracellular domain, a transmembrane region, a cystathionine-β-synthase (CBS) pair domain, and a cyclic nucleotide-binding homology domain[1][4]. It is primarily expressed in the testis and brain, with lower levels in other tissues, and is implicated in maintenance of magnesium homeostasis, copper binding, and germ cell differentiation[4][5]. Mutations in CNNM1 are associated with inherited diseases such as Jalili syndrome, familial hypomagnesemia, and have also been implicated in cancer development and metastasis, as well as in other disorders[3][4][5]. Its exact transport function remains under study, with evidence suggesting both direct and regulatory roles in cation trafficking[1][4]. No established drugs or mechanism-based interacting therapies are currently described for CNNM1, but the protein is under investigation as a potential therapeutic target in oncology and metabolic disease models.

Other names

Metal transporter CNNM1ACDP1SLC70A1Ancient conserved domain-containing protein 1Cyclin-M1CLP-1CNNM1phCNNM1Q9NRU3