Target intelligence / Profile preview

Cyclin B1 (CCNB1)

Target: CCNB1
Molecular classification: Cyclin

Overview

Cyclin B1 (CCNB1) is a regulatory protein crucial for cell cycle progression, specifically involved in the control of mitosis. It forms a complex with cyclin-dependent kinase 1 (Cdk1) to create the maturation-promoting factor (MPF), which orchestrates chromosome condensation, nuclear envelope breakdown, and spindle pole assembly. Its activity is tightly regulated and alterations in its expression are associated with various cancers.

Mechanism of action

Cdk1/p34cdc2 activation/inhibition

Biological functions

Cell cycleRegulation of G2/M transitionMitosis

Disease associations

Cancer

Safety considerations

Uncontrolled cell divisionPotential for polyploidization or senescence if inhibited improperly

Biomarkers

CCNB1 expression levels as a predictive marker in cancer

Beyond the preview

Go deeper on Cyclin B1 (CCNB1).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Cyclin B1 (CCNB1).

Explore the full profile