Gosset Molecular Classification
Cyclin
Other Names
Cyclin B₁
Disease Roles
Cyclin B1 Overview
Cyclin B1 (CCNB1) is a regulatory protein essential for entry into and progression through mitosis. It forms a complex with Cdk1 to create maturation-promoting factor (MPF), which controls chromosome condensation, nuclear envelope breakdown, and spindle assembly. Its expression peaks during the G₂/M phase and is tightly regulated to ensure proper timing of mitosis. Dysregulation of CCNB1 is implicated in various cancers.
Mechanism of Action
Inhibition of CCNB1/CDK1 complex
Biological Functions
Cell cycle
Regulation of mitosis
Disease Associations
Cancer
Safety Considerations
- Potential for off-target effects on normal cell division
- Myelosuppression
Associated Biomarkers
| Biomarker |
|---|
| CCNB1 expression levels as prognostic marker in certain cancers |