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Target intelligence / Profile preview
Cyclin B1 Ubiquitination
- Molecular classification
- Post-translational modification, Ubiquitination pathway
01
Overview
Cyclin B1 ubiquitination refers to the post-translational modification process in which ubiquitin molecules are covalently attached to cyclin B1, marking it for degradation by the 26S proteasome. This process is essential for proper cell cycle progression, particularly for mitotic exit. The primary E3 ubiquitin ligase responsible for targeting cyclin B1 is the Anaphase-Promoting Complex/Cyclosome (APC/C). Failure or dysregulation in this process can result in mitotic arrest, aneuploidy, and uncontrolled proliferation.
02
Mechanism of action
Inhibition of cullin-RING ligases, leading to cell cycle arrest
03
Biological functions
Cell cycle regulationMitotic exitProtein degradation
04
Disease associations
CancerAneuploidy
05
Safety considerations
Potential for off-target effects due to broad inhibition of cullinsDisruption of normal cell cycle progression in healthy cells
06
Interacting drugs
MLN4924
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