Cyclin D-binding Myb-like transcription factor 1 (DMTF1)

Cyclin D-binding Myb-like transcription factor 1 (DMTF1) is a transcription factor with a cyclin D-binding domain and Myb-like repeats, functioning as a tumor suppressor largely via activation of the ARF–p53 pathway; it mediates growth arrest and apoptosis in response to oncogenic stress (notably Ras pathway activation), and plays important roles in cell cycle regulation, hematopoietic differentiation, and transcription of specific genes such as ARF and aminopeptidase N. DMTF1 is present in multiple isoforms, with the α isoform serving as a potent transcriptional activator and tumor suppressor, while β and γ isoforms can antagonize α function, sometimes promoting proliferation. Deletions, aberrant splicing, or downregulation of DMTF1 are implicated in the pathogenesis of several cancer types.

Other names

DMP1hDMTF1hDMP1DMTFMRULCyclin-D-interacting Myb-like protein 1cyclin D-binding Myb-like proteinCyclin-D-binding Myb-like transcription factor 1cyclin-D-interacting Myb-like protein 1

Not directly targeted by approved drugs (as of current knowledge); Potential indirect action by modulation of ARF–p53 pathway, Ras signaling, or splicing regulators