Cyclin D1 messenger RNA (CCND1 mRNA) (CCND1 mRNA)

Cyclin D1 messenger RNA (CCND1 mRNA) is the transcript of the CCND1 gene, which encodes a protein essential for the transition of cells from the G1 to the S phase of the cell cycle (UniProt P24385). The Cyclin D1 protein functions by activating cyclin-dependent kinases CDK4 and CDK6, which in turn phosphorylate the retinoblastoma protein to release transcription factors necessary for DNA replication (PubMed, PMID: 25730344). Overexpression of CCND1 mRNA is a hallmark of several malignancies, most notably mantle cell lymphoma, where it often results from the t(11;14) chromosomal translocation (StatPearls, Mantle Cell Lymphoma). In addition to lymphoma, elevated levels of this mRNA are frequently observed in breast, colon, and lung cancers, often correlating with poor prognosis and resistance to standard therapies (PubMed, PMID: 30236311). Therapeutic strategies targeting the mRNA, such as antisense oligonucleotides like BP1002, aim to reduce protein levels by inducing the degradation of the transcript or blocking its translation (Bio-Path Holdings, 2024). This approach provides a means to inhibit the oncogenic drive in tumors that are dependent on Cyclin D1 for survival and proliferation. By targeting the mRNA directly, these therapies can potentially bypass resistance mechanisms that arise against downstream CDK4/6 inhibitors. Current clinical development focuses on using liposomal delivery systems to enhance the stability and uptake of these RNA-targeting agents in tumor cells.

Other names

CCND1 mRNABCL1 mRNAPRAD1 mRNAG1/S-specific cyclin-D1 mRNA

Antisense inhibition involving the sequence-specific binding of oligonucleotides to the CCND1 mRNA, which triggers RNase H-mediated cleavage and degradation of the transcript, thereby preventing the translation of the Cyclin D1 protein (Bio-Path Holdings, 2024).