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Target intelligence / Profile preview
Cyclin-dependent kinase 1 (CDK1)
- Target
- CDK1
- Molecular classification
- Enzyme, Serine/threonine protein kinase
01
Overview
Cyclin-dependent kinase 1 (CDK1) is a highly conserved serine/threonine protein kinase that plays a central role in regulating the eukaryotic cell cycle. It is essential for the control of both mitosis and meiosis, driving transitions between key phases of the cell cycle. CDK1 forms complexes with various cyclins—most notably cyclin B—to create the M-phase promoting factor (MPF), which is crucial for progression from G2 to M phase. Overexpression or dysregulation of CDK1 has been implicated in various cancers, and inhibition of CDK1 is being explored therapeutically.
- Other names
- CDC2CDC28Ap34 protein kinasecell division cycle 2 homolog A
02
Mechanism of action
Phosphorylation of numerous substrates (>75 identified in yeast) involved in orchestrating cellular events required for successful mitosis/meiosis.
03
Biological functions
Cell cycleMitosisMeiosisDNA replication/segregationmRNA transcriptionDNA repairCentrosome duplicationNuclear envelope breakdownSpindle formationChromosome condensation/alignment/separation
04
Disease associations
CancerBreast cancerColorectal cancerEsophageal adenocarcinomaGastric cancerLiver cancerLung cancerOvarian cancerOral squamous cell carcinoma
05
Safety considerations
Off-target effects on related kinasesChemoresistance
06
Interacting drugs
Dinaciclib
1 more in the full profile.
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