Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Cyclin-dependent kinase 1-cyclin B complex (CDK1-cyclin B complex)
- Target
- CDK1-cyclin B complex
- Molecular classification
- Protein complex, Kinase complex, Cyclin-dependent kinase complex
01
Overview
The cyclin-dependent kinase 1-cyclin B complex is a key regulator of the cell cycle, specifically controlling the transition from G2 phase to M phase (mitosis). It consists of CDK1, a serine/threonine kinase, and cyclin B, its regulatory subunit. The complex orchestrates essential mitotic events like chromosomal condensation, spindle formation, and nuclear envelope breakdown. Dysregulation of this complex can lead to uncontrolled cell proliferation and is implicated in cancer.
- Other names
- CDK1/Cyclin Bp34cdc2-cyclin BMPF (Maturation Promoting Factor)
02
Mechanism of action
CDK1 inhibitors block the kinase activity of the CDK1-cyclin B complex, preventing cell cycle progression and promoting cell death.
03
Biological functions
Cell cycle regulationG2/M transitionMitosisSpindle assemblyChromosomal condensationNuclear envelope breakdown
04
Disease associations
CancerUncontrolled cell proliferation
05
Safety considerations
Potential for off-target effects due to the involvement of CDK1 in multiple cellular processes.Toxicity associated with cell cycle disruption.
Beyond the preview
Go deeper on Cyclin-dependent kinase 1-cyclin B complex (CDK1-cyclin B complex).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Cyclin-dependent kinase 1-cyclin B complex (CDK1-cyclin B complex).