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Target intelligence / Profile preview
Cyclin-dependent kinase 1 regulatory subunit 2 (CCNB1)
- Target
- CCNB1
- Molecular classification
- Cyclin, Regulatory Protein
01
Overview
Cyclin B1 (CCNB1) is a regulatory protein essential for controlling the cell cycle at the G2/M transition. It forms a complex with cyclin-dependent kinase 1 (CDK1), creating the maturation-promoting factor (MPF), which is crucial for initiating mitosis. Overexpression of CCNB1 is observed in various cancers and associated with aggressive tumor behavior and poor clinical outcomes, making it a potential therapeutic target.
- Other names
- Cyclin B1G2/mitotic-specific cyclin-B1
02
Mechanism of action
Inhibition of CDK activity through disruption of cyclin binding or by targeting upstream regulators of CCNB1.
03
Biological functions
Cell cycleRegulation of CDK1 activityMitosisChromosome condensationNuclear envelope breakdownSpindle assembly
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to the critical role of cell cycle regulation in normal cells.Development of resistance.
06
Biomarkers
CCNB1 mRNA expressionCyclin B1 protein levels
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