Cyclin-dependent kinase 11A pseudogene

Cyclin-dependent kinase 11A pseudogene is a nonfunctional genomic sequence that shares high sequence similarity with the protein-coding cyclin-dependent kinase 11A (CDK11A) but harbors mutations or deletions that prevent it from encoding a functional protein[3][1][5]. Pseudogenes such as this arise from gene duplication or retrotransposition events followed by the accumulation of disabling mutations, and they do not function as active kinases, receptors, or other types of protein targets. While most pseudogenes are considered nonfunctional genetic relics, some can be transcribed into non-coding RNAs with potential regulatory effects, but such roles are typically gene- and context-specific and not established for this entry[3][1]. ENSG00000259346 does not encode a functional protein kinase or any receptor/enzyme known to have therapeutic relevance. Common confusion occurs because the functional gene, CDK11A (e.g., ENSG00000008128), encodes an active serine/threonine kinase with known cell cycle and apoptosis regulatory roles, but the "pseudogene" form does not replicate these functions[2][4]. As a pseudogene, it is not considered a therapeutic target, lacks canonical abbreviation, direct roles in pharmacology or disease, and does not interact with drugs. If a request is made for database entries or druggability, all such queries generally refer to the active gene or protein, not to the pseudogene. ENSG00000259346 refers to a **pseudogene**, not a protein-coding gene, and therefore is not recognized as a therapeutic target. There is nothing to suggest it is a misspelling, but it is incorrect in the drug target context since pseudogenes do not fulfill molecular targeting or therapeutic functions[3][5][1].

Other names

CDK11A pseudogeneCDC2L2 pseudogenePITSLRE pseudogene