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Cyclin Dependent Kinase 19 (None)
- Target
- None
- Molecular classification
- Enzyme, Serine/threonine kinase, Cyclin-dependent kinase, Transcription factor, Member of the Mediator/CDK8 subfamily
01
Overview
Cyclin dependent kinase 19 (CDK19) is a serine/threonine protein kinase and a member of the cyclin-dependent kinase family, specifically within the CDK8 subfamily. It functions as part of a four-protein Mediator kinase module that associates with the larger Mediator complex, which regulates RNA Polymerase II-mediated gene expression. It is involved in transcriptional regulation, cell cycle control, and immune responses. Dysregulation is linked to developmental disorders and cancer.
- Other names
- CDC2L6CDC2-related protein kinase 6CDK11
02
Mechanism of action
Inhibition of CDK19 kinase activity to modulate transcription and cell cycle progression.
03
Biological functions
Transcriptional regulationCell cycleCell proliferationImmune responseInflammatory response
04
Disease associations
CancerNeurodevelopmental disordersDevelopmental And Epileptic Encephalopathy type 87 (DEE87)
05
Safety considerations
Potential for off-target effects due to homology with other kinasesDisruption of normal cell cycle regulation leading to toxicityImpact on immune function requiring careful monitoring
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