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Target intelligence / Profile preview
Cyclin-dependent kinase 2 (CDK2)
- Target
- CDK2
- Molecular classification
- Enzyme, Serine/threonine protein kinase
01
Overview
Cyclin-dependent kinase 2 (CDK2) is a serine/threonine protein kinase that plays a central role in cell cycle regulation. It controls progression through the G1/S boundary and drives cells through S phase when complexed with cyclins E or A. Activation requires cyclin binding and phosphorylation at Thr160. Dysregulation of CDK2 is implicated in various cancers, making it a target for anticancer drug development.
02
Mechanism of action
Inhibition of CDK2 kinase activity, often through ATP-competitive or allosteric mechanisms.
03
Biological functions
Cell cycleG1/S transition controlS-phase progression
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to homology with other kinases.Toxicity related to disruption of normal cell cycle progression.
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