Cyclin-dependent kinase 2-associated protein 2 (CDK2AP2)

Cyclin-dependent kinase 2-associated protein 2 (CDK2AP2) is a protein-coding gene encoding a protein that interacts with cyclin-dependent kinase 2-associated protein 1 (CDK2AP1).[3] CDK2AP2 is a component of the NuRD (Nucleosome Remodeling and Deacetylase) chromatin remodeling complex, participating in chromatin remodeling in the nucleus.[3] It inhibits the cell cycle G1/S phase transition by repressing CDK2 expression and activity, thereby suppressing CDK2 interaction with cyclins E and A.[3] CDK2AP2 also plays a role in regulating the self-renewal of embryonic stem cells and is involved in maintaining their survival during differentiation, as demonstrated in mouse embryonic stem cells.[2][3] In oocytes, it regulates microtubule organization during meiosis and has roles in terminal oocyte maturation.[2][3] Disease associations include developmental disorders, but its direct role in cancer or as a therapeutic target is not established.[3] Note: - CDK2AP2 is distinct from Cyclin-dependent kinase 2 (CDK2), which is a kinase and established drug target. CDK2AP2 itself is not recognized as a therapeutic target, receptor, enzyme, transporter, ion channel, or established biomarker based on current literature.[3][2] - No drugs currently interact directly with CDK2AP2, and no mechanisms of action, biomarkers, or safety concerns specific to targeting CDK2AP2 have been described in available databases or the literature.[3][2]

Other names

Cyclin-dependent kinase 2-associated protein 2CDK2AP2DOC1RCDK2-associated protein 2DOC-1Rp14DOC-1-related proteintumor suppressor deleted in oral cancer related 1