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Cyclin-dependent kinase 3
- Molecular classification
- Enzyme, Protein kinase, Serine/threonine-protein kinase, Cyclin-dependent kinase
01
Overview
Cyclin-dependent kinase 3 (CDK3) is a serine/threonine protein kinase that plays a role in cell cycle control, particularly at the G0-G1 and G1-S transitions. It requires interaction with cyclins for activation and can phosphorylate histone H1. Recent studies suggest it may have oncogenic properties and be involved in cancer progression. While it's a potential therapeutic target, current inhibitors primarily focus on other CDK family members.
- Other names
- CDK3Cell division protein kinase 3
02
Mechanism of action
CDK3 inhibitors (not specific, as most target other CDKs like 2/4/6/7/9)
03
Biological functions
Cell cycle regulationG0-G1 transitionG1-S transitionHistone H1 phosphorylation
04
Disease associations
CancerEsophageal squamous cell carcinomaLung cancerSkin cancer
05
Safety considerations
Potential for off-target effects due to sequence similarity with other CDKsInhibition of essential cell cycle processes
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