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Target intelligence / Profile preview
Cyclin-dependent kinase 8 (None)
- Target
- None
- Molecular classification
- Enzyme, Protein Kinase, Serine/threonine protein kinase, Transcription factor
01
Overview
Cyclin-dependent kinase 8 (CDK8) is a serine/threonine protein kinase that belongs to the cyclin-dependent kinase family. It forms a complex with cyclin C and is primarily known for its role in regulating transcription as part of the Mediator complex. CDK8 is an oncogenic driver in multiple cancers, activating pathways like Wnt/β-catenin and regulating estrogen-inducible genes. High CDK8 levels are associated with poor prognosis in certain cancers. It functions through phosphorylation events affecting target proteins involved in gene regulation. Inhibitors like Senexin A block its ATP-binding pocket.
- Other names
- CDK8K35cyclin-dependent kinase 8IDDHBA
02
Mechanism of action
Inhibition of CDK8 kinase activity
03
Biological functions
Transcriptional regulationPhosphorylationRegulation of gene expressionMediator complex function
04
Disease associations
CancerColorectal cancerBreast cancerHematological malignanciesUterine leiomyosarcoma
05
Safety considerations
Potential for off-target effects due to kinase family similaritiesContext-dependent tumor-suppressive functions in certain cellular contexts
06
Interacting drugs
Senexin A
07
Biomarkers
CDK8 expression level (prognostic marker)
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