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Target intelligence / Profile preview
Cyclin-dependent kinase inhibitor 1 (CDKN1A)
- Target
- CDKN1A
- Molecular classification
- CDK Inhibitor, Tumor Suppressor, Transcription factor regulator
01
Overview
Cyclin-dependent kinase inhibitor p21 (also known as p21^Cip1/Waf1) is a critical regulator of the cell cycle, DNA replication, and apoptosis with important roles in tumor suppression and cellular stress responses. It inhibits CDKs, interacts with PCNA, and its expression is regulated by p53.
- Other names
- p21p21Cip1/Waf1CDKIp21Cip1WAF1
02
Mechanism of action
Inhibition of cyclin-dependent kinases (CDKs), interaction with PCNA
03
Biological functions
Cell cycle arrestDNA repair facilitationApoptosis modulationSenescence inductionRegulation of DNA replication
04
Disease associations
CancerAgingCellular stress response
05
Safety considerations
Dual role in cancer (tumor suppressor vs. anti-apoptotic)Potential for off-target effects due to interactions with multiple CDKs and PCNA
06
Biomarkers
p21 expression levels as a prognostic marker in cancer
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