Cyclin-dependent kinase-like 2 (CDKL2)

Cyclin-dependent kinase-like 2 is a CDC2-related serine/threonine protein kinase encoded by the CDKL2 gene in humans. The protein accumulates primarily in the cytoplasm, with lower levels detected in the nucleus. It is classified as part of a large family of protein kinases structurally related to cyclin-dependent kinases but is considered a distinct entity. While it possesses protein kinase activity, specific biological functions and disease associations are less well-characterized compared to classical CDKs such as CDK1 or CDK2. CDKL2 is not synonymous with CDK2 or classical cyclin-dependent kinases, though they share similarity in sequence and domain architecture. The correct canonical name is Cyclin-dependent kinase-like 2 (CDKL2). It is an enzyme, specifically a serine/threonine kinase, belonging to the CDC2-related protein kinase family. Its biological role is phosphorylation of protein substrates, potentially affecting cellular signaling and possibly cell cycle regulation, but the specifics are not well established in public domain sources. There are no reported drugs, biomarkers, or major toxicology concerns linked to CDKL2 as of the information available in current search results.

Other names

cyclin-dependent kinase like 2CDKL2