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Target intelligence / Profile preview
Cyclin-dependent kinase-related kinase 2 (EtCRK2)
- Target
- EtCRK2
- Molecular classification
- Enzyme, Serine/threonine protein kinase, Cyclin-dependent kinase
01
Overview
Cyclin-dependent kinase-related kinase 2 (EtCRK2) is a cyclin-dependent kinase (CDK) identified in the apicomplexan parasite Eimeria tenella. It is closely related to eukaryotic CDKs, which are serine/threonine protein kinases that regulate cell cycle progression. EtCRK2 plays a critical role in regulating the cell cycle during both asexual and sexual stages of E. tenella's life cycle. It requires association with specific cyclins for full activation. Given its central role in parasite replication and development—and its divergence from host kinases—EtCRK2 represents an attractive target for anti-coccidial drug discovery efforts.
02
Mechanism of action
Inhibition of kinase activity to disrupt cell cycle progression and parasite replication.
03
Biological functions
Cell cycle regulationAsexual reproductionSexual reproductionDNA synthesis initiationG1/S transitionS phase progressionMeiosis
04
Disease associations
InfectionCoccidiosis
05
Safety considerations
Potential for off-target effects on host kinases.Development of drug resistance.
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