Target intelligence / Profile preview

Cyclin E (None)

Target: None
Molecular classification: Cyclins, Transcription factor

Overview

Cyclin E is a member of the cyclin protein family that regulates the cell cycle, particularly the transition from G1 phase to S phase. It forms a complex with CDK2, phosphorylating substrates like Rb and promoting DNA synthesis. Cyclin E deregulation is frequently observed in various cancers, which can lead to uncontrolled cell proliferation. Cyclin E also has kinase-independent functions, like facilitating MCM helicase loading onto chromatin.

Other names: CCNE1Cyclin E1CCNE2Cyclin E2

Mechanism of action

CDK2 inhibition (potential)

Biological functions

Cell cycleG₁/S transitionOrigin licensingCentrosome duplicationDNA replication

Disease associations

Cancer

Safety considerations

Uncontrolled cell proliferationGenomic instability

Biomarkers

Cyclin E overexpression

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