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Target intelligence / Profile preview
Cyclin E
- Molecular classification
- Cyclins, Transcription factor
01
Overview
Cyclin E is a member of the cyclin protein family that regulates the cell cycle, particularly the transition from G1 phase to S phase. It forms a complex with CDK2, phosphorylating substrates like Rb and promoting DNA synthesis. Cyclin E deregulation is frequently observed in various cancers, which can lead to uncontrolled cell proliferation. Cyclin E also has kinase-independent functions, like facilitating MCM helicase loading onto chromatin.
- Other names
- CCNE1Cyclin E1CCNE2Cyclin E2
02
Mechanism of action
CDK2 inhibition (potential)
03
Biological functions
Cell cycleG₁/S transitionOrigin licensingCentrosome duplicationDNA replication
04
Disease associations
Cancer
05
Safety considerations
Uncontrolled cell proliferationGenomic instability
06
Biomarkers
Cyclin E overexpression
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