Target intelligence / Profile preview

Cyclin E1 (CCNE1)

Target: CCNE1
Molecular classification: Cyclins, Cyclin E subfamily, Cell cycle regulatory protein

Overview

Cyclin E1 (CCNE1) is a key regulatory protein that controls the transition from G1 to S phase in the cell cycle by forming a complex with and activating cyclin-dependent kinase 2 (CDK2). Overexpression or amplification of CCNE1 is frequently observed in various cancers and is associated with poor prognosis due to increased genomic instability and uncontrolled proliferation.

Other names: G1/S-specific cyclin-E1CCNE

Mechanism of action

Forms a complex with CDK2 to promote cell cycle progression from G1 to S phase. Regulated by phosphorylation and ubiquitination leading to proteasomal degradation.

Biological functions

Cell cycle regulationG1/S transitionDNA replicationRegulation of transcription involved in G1/S transition

Disease associations

CancerOvarian cancerHepatocellular carcinoma (HCC)Breast cancer (BRCA)Lung adenocarcinoma (LUAD)Endometrial carcinoma (UCEC)TumorigenesisChromosome instability

Safety considerations

Genomic instabilityIncreased cell proliferationEpithelial-mesenchymal transition (EMT)Impaired DNA repair mechanisms

Biomarkers

CCNE1 overexpressionCCNE1 amplification

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