Cyclin L1 (CCNL1)

Cyclin L1 is a nuclear cyclin-family protein characterized by a serine-arginine (RS) rich domain acting as a nuclear localization signal and directing the protein to nuclear speckles, sites of active RNA splicing. Cyclin L1 forms complexes with cyclin-dependent kinases such as CDK11 and CDK12 to regulate alternative pre-mRNA splicing, playing a key role in early cellular responses to growth factors and cell cycle transitions, particularly G0–G1. Its gene, CCNL1, is frequently amplified and overexpressed in head and neck squamous cell carcinoma, suggesting a role in oncogenic progression via alteration of splicing patterns of apoptosis-related genes. Cyclin L1’s physiological significance may extend to influencing developmental traits such as birth weight. There are currently no drugs targeting cyclin L1 directly, and no significant safety concerns have been described for cyclin L1 modulation in therapeutic contexts.

Other names

Cyclin-L1CCNL1BM-001UNQ530/PRO1073Cyclin-Lania-6aANIA6ACyclin L gammaPRO1073