Cyclin O (CCNO)

Cyclin O is an atypical member of the cyclin protein family encoded by the CCNO gene. It is essential for the differentiation of multiciliated cells, where it functions downstream of key transcriptional regulators (like multicilin) to drive centriole amplification and the proper formation and function of deuterosomes. This process underlies the assembly of multiple motile cilia, which are critical for effective mucociliary clearance in respiratory epithelia and in other ciliated tissues. Loss-of-function mutations in CCNO impair centriole amplification and cilia formation, clinically manifesting as primary ciliary dyskinesia, reduced cilia generation, chronic lung disease, hydrocephalus, and infertility. Cyclin O is not generally considered a therapeutic target such as a receptor, enzyme, or transporter; instead, it is a cell cycle–regulating protein mainly implicated in developmental biology and disease pathogenesis through loss-of-function mutations[1][2][4].

Other names

UDG2FLJ22422UNG2CCNUCILD29cyclin-Ocyclin Ucyclin domain containingCyclin-O