Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Cyclin Y-like protein 1 (CCNYL1)
- Target
- CCNYL1
- Molecular classification
- Cyclin family protein
01
Overview
Cyclin Y-like protein 1 (CCNYL1) is a member of the **cyclin family**, structurally related to cyclin Y (CCNY), and primarily functions as a regulatory subunit for cell cycle-associated kinases. It binds to cyclin-dependent kinase 16 (CDK16), promoting kinase stabilization and activity. CCNYL1 is highly expressed in the testis, where it is essential for sperm maturation and male fertility; knockout models exhibit profound defects in sperm motility due to disrupted phosphorylation events necessary for proper sperm structure. It also modulates Wnt/β-catenin signaling in mammalian development, with roles in mammary stem cell function and embryogenesis. CCNYL1 acts at the plasma membrane and coordinates various signaling pathways required for neurodevelopment and tissue expansion. There are currently no drugs targeting CCNYL1 directly, nor any evidence for a therapeutically relevant "CCNYL1B" isoform or paralog.
- Other names
- cyclin Y-like protein 1CCNYL1putative cyclin-Y-like protein 3
02
Biological functions
Cell cycle regulationWnt/β-catenin signalingSpermatogenesis (via interaction with CDK16)Embryonic developmentRegulation of phosphorylation events in sperm maturationNeurogenesis (Wnt/STOP signaling)
03
Disease associations
Male infertility (defective spermatogenesis and sperm motility)Developmental disorders (embryonic lethality when both CCNY and CCNYL1 are absent)
Beyond the preview
Go deeper on Cyclin Y-like protein 1 (CCNYL1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Cyclin Y-like protein 1 (CCNYL1).