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Target intelligence / Profile preview
Cyclo-oxygenase 1 (COX-1)
- Target
- COX-1
- Molecular classification
- Enzyme, Dioxygenase, Peroxidase
01
Overview
Cyclo-oxygenase 1 (COX-1), also known as prostaglandin-endoperoxide synthase 1 (PTGS1), is an enzyme that catalyzes the conversion of arachidonic acid to prostaglandin H2 (PGH2), a precursor for various prostanoids including prostaglandins and thromboxanes. COX-1 is constitutively expressed in most tissues and plays a central role in maintaining physiological homeostasis, including gastric protection, platelet aggregation, and renal function. It is a target of nonsteroidal anti-inflammatory drugs (NSAIDs), and its inhibition can lead to gastrointestinal side effects.
- Other names
- Prostaglandin-endoperoxide synthase 1PTGS1Prostaglandin G/H synthase 1
02
Mechanism of action
Inhibition of cyclooxygenase activity, reducing prostaglandin and thromboxane synthesis.
03
Biological functions
Prostaglandin biosynthesisThromboxane biosynthesisGastric protectionPlatelet aggregationRenal homeostasis
04
Disease associations
InflammationPainFeverGastrointestinal ulceration
05
Safety considerations
Gastrointestinal side effects (ulcers, bleeding)Impaired platelet aggregationRenal dysfunction
06
Interacting drugs
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
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