Target intelligence / Profile preview

Cyclooxygenase-3 (COX-3)

Target: COX-3
Molecular classification: Enzyme, Oxygenase, Peroxidase

Overview

Cyclooxygenase-3 (COX-3) is a variant enzyme related to the cyclooxygenase family, encoded by the PTGS1 (COX1) gene. It differs from COX-1 due to alternative mRNA splicing. While COX-3 may be a functional enzyme in some species, in humans, the translated protein lacks significant cyclooxygenase activity and is unlikely to play any physiological role in prostaglandin synthesis. Acetaminophen may selectively inhibit canine COX-3, but this mechanism is not relevant in humans.

Other names: PTGS1 variant

Mechanism of action

Cyclooxygenase inhibition (in some species)

Biological functions

Prostaglandin synthesis (in some species)Pain modulation (in some species)Fever regulation (in some species)

Disease associations

Inflammation (in some species)Pain (in some species)Fever (in some species)

Safety considerations

Species-specific differences in function and drug responseLimited clinical relevance in humans

Interacting drugs

Acetaminophen

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