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Target intelligence / Profile preview
Cyclooxygenase type 2 (COX-2)
- Target
- COX-2
- Molecular classification
- Enzyme
01
Overview
Cyclooxygenase-2 (COX-2), also known as prostaglandin-endoperoxide synthase 2 (PTGS2), is an enzyme that catalyzes the conversion of arachidonic acid to prostaglandin H₂ (PGH₂). It is a key mediator of inflammation, being upregulated during inflammatory responses and driving the production of pro-inflammatory prostanoids. Selective COX-2 inhibitors are used as anti-inflammatory drugs, but some have been linked to cardiovascular risks.
- Other names
- Prostaglandin-endoperoxide synthase 2PTGS2
02
Mechanism of action
Selective inhibition of COX-2 enzymatic activity
03
Biological functions
Catalysis of arachidonic acid to prostaglandin H₂InflammationProstaglandin synthesis
04
Disease associations
InflammationPainCancerCardiovascular disease
05
Safety considerations
Cardiovascular risksGastrointestinal side effects (less than non-selective NSAIDs)
06
Interacting drugs
Celecoxib
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