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Target intelligence / Profile preview
Cyclophosphamide (CTX)
- Target
- CTX
- Molecular classification
- Alkylating agent, Nitrogen mustard derivative, Prodrug
01
Overview
Cyclophosphamide is a synthetic antineoplastic alkylating agent used to treat various cancers and autoimmune conditions. It is a prodrug that requires metabolic activation to form phosphoramide mustard, which alkylates DNA, disrupting replication and transcription, leading to cell death. It also possesses immunosuppressive properties.
02
Mechanism of action
DNA alkylation and crosslinking after metabolic activation, leading to cell cycle arrest and apoptosis.
03
Biological functions
DNA alkylationDNA crosslinkingCell cycle arrestApoptosis inductionImmunosuppression
04
Disease associations
CancerAutoimmune diseases
05
Safety considerations
Immunosuppression/leukopeniaHemorrhagic cystitisGonadal toxicity/ovarian failureCardiotoxicitySecondary malignancies (bladder cancer, leukemia, lymphoma)
06
Interacting drugs
Etoposide
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