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Target intelligence / Profile preview
CYFIP-related Rac1 interactor B (CYRIB)
- Target
- CYRIB
- Molecular classification
- Other (actin regulatory protein, small GTPase effector)
01
Overview
CYFIP-related Rac1 interactor B (CYRIB) is a cytosolic protein that regulates the actin cytoskeleton by negatively modulating RAC1 signaling and limiting actin polymerization, particularly by inhibiting the Scar/WAVE complex[1][2][5]. This protein helps control cell migration, chemotaxis, and polarization by focusing protrusive signals and restraining the complexity of pseudopodia. CYRIB plays a role in defending against bacterial entry (notably Salmonella, Listeria, and Mycobacterium), modulates mitochondrial fission and oxidative stress, and is implicated in certain diseases such as cancer, cardiomyopathy, and spinocerebellar ataxia[1][2][5]. No approved drugs are currently known to target CYRIB directly, and its utility as a biomarker or the safety considerations in therapeutic targeting remain undefined in the literature[1][2][5].
- Other names
- FAM49BCYRI-BCYRIBM-009L1family with sequence similarity 49 member Bprotein FAM49BCYFIP related Rac1 interactor BFAM49B/JPH1 fusionMTSS1/FAM49B fusion
02
Biological functions
Negative regulation of actin filament polymerizationnegative regulation of RAC1 signalingcytoskeletal remodelingregulation of mitochondrial fissioncell migrationepithelial polarizationprotection against bacterial infectionregulation of oxidative stress
03
Disease associations
CancerInfection (Salmonella, Mycobacterium tuberculosis, Listeria monocytogenes)CardiomyopathySpinocerebellar ataxia
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