Target intelligence / Profile preview

Cystathionine beta-synthase (CBS)

Target: CBS
Molecular classification: Enzyme

Overview

Cystathionine beta-synthase (CBS) is an enzyme that catalyzes the first and rate-limiting step in the transsulfuration pathway, converting homocysteine and serine into cystathionine. This process is crucial for amino acid metabolism, sulfur homeostasis, and cellular redox balance. Mutations in CBS are associated with homocystinuria.

Other names: β-thionaseCysteinesynthaseL-serin hydrolyaseSerinesulfhydrase

Mechanism of action

CBS inhibitors (experimental)

Biological functions

Amino acid metabolismSulfur homeostasisRedox balanceHomocysteine detoxificationHydrogen sulfide production

Disease associations

HomocystinuriaCardiovascular diseaseCancerDown syndrome

Safety considerations

Inhibition may disrupt sulfur metabolism and H2S production

Biomarkers

Homocysteine levels

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