Target intelligence / Profile preview

Cystatin-11 (CST11)

Target: CST11
Molecular classification: Cysteine protease inhibitor, Type 2 cystatin family, Antimicrobial peptide

Overview

Cystatin-11 is a member of the type 2 cystatin family encoded by the CST11 gene, located at the cystatin locus on chromosome 20. It is expressed specifically in the epididymis, where it may contribute to sperm maturation and fertilization. The protein exhibits cysteine protease inhibitor activity and has antibacterial properties, particularly against Escherichia coli. Its function appears limited to the male reproductive tract, and there are no known drug interactions or biomarker uses for CST11 in clinical settings[1][2][3][5][6][7].

Other names: Cystatin-11CST11CST8LdJ322G13.6CTES2SC13SC13deltacystatin-related epididymal-specific proteinepididymis secretory sperm binding protein

Biological functions

Inhibition of cysteine-type endopeptidase activityDefense response to Gram-negative bacteriaPotential role in sperm maturation and fertilization

Disease associations

Other (no direct links to major disease classes, but associated with certain syndromes per gene-disease databases)

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