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Cystatin-9-like (CST9L)
- Target
- CST9L
- Molecular classification
- Other (member of the cystatin superfamily), Cysteine proteinase inhibitor superfamily (Type 2 cystatin family, but CST9L lacks critical consensus sites for inhibitory function)
01
Overview
Cystatin-9-like (CST9L) is a protein-coding gene located on chromosome 20 and a member of the cystatin superfamily, sharing sequence similarity with cysteine protease inhibitors but lacking critical consensus sites required for inhibitory activity[2][7]. CST9L is expressed predominantly in the testis, suggesting involvement in tissue reorganization during early testicular development[2][5]. It is bioinformatically annotated with possible roles in antimicrobial response and endopeptidase inhibition[4], but definitive biochemical function remains unverified. CST9L is not currently considered a therapeutic target or disease biomarker, nor are drugs documented to interact directly with it[2][7].
- Other names
- Cystatin-9-likeCST9LCTES7BUNQ1835/PRO3543bA218C14.1Testatintesticular tissue protein Li 45
02
Biological functions
Likely involved in tissue reorganization during early testis development (based on testis-specific expression)Possible role in hematopoietic differentiation (by similarity to paralogs)Predicted cysteine-type endopeptidase inhibitor activity (based on sequence)Predicted antimicrobial humoral response (bioinformatic annotation)
03
Disease associations
Acute contagious conjunctivitisAcute conjunctivitis (associated, not causative)
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