Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Cysteine and glycine-rich protein 1 (CSRP1)
- Target
- CSRP1
- Molecular classification
- LIM domain protein, Scaffold protein, Cytoskeletal-associated protein, Transcriptional regulator
01
Overview
Cysteine and glycine-rich protein 1 (CSRP1) is a LIM domain-containing scaffold protein, widely expressed in mammalian tissues, and highly conserved across vertebrates and invertebrates. CSRP1 functions in gene regulation, cytoskeletal organization, and acts as an integrator in multiprotein complexes governing smooth muscle differentiation, cell migration, and morphogenesis. It regulates expression of genes via interaction with transcription factors like serum response factor (SRF) and GATA proteins; participates in cytoskeletal remodeling via associations with zyxin; and modulates cellular movement and tissue organization via interactions with key signaling pathways such as the noncanonical Wnt and JNK pathways. Aberrant expression or methylation of CSRP1 is implicated in various pathologies including vascular disorders, fibrotic diseases, and cancers such as hepatocellular carcinoma.
- Other names
- CRP1CSRPCYRPCRPHEL-141D1S181EHEL-S-286Epididymis luminal protein 141
02
Biological functions
Regulation of gene expressionCell growthSomatic differentiationCytoskeletal remodelingSmooth muscle differentiationCell migration and morphogenesis
03
Disease associations
Cancer (e.g., hepatocellular carcinoma: promoter hypermethylation, biomarker role)Cardiovascular disease (implicated in vascular biology, smooth muscle response to stress)Fibrosis (expressed in lung fibrosis, involved in TGF-β1 pathways)Other (developmental cardiac defects; cardiac bifida in model organisms)
04
Biomarkers
Promoter hypermethylation in hepatocellular carcinoma (as a potential diagnostic biomarker)
Beyond the preview
Go deeper on Cysteine and glycine-rich protein 1 (CSRP1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Cysteine and glycine-rich protein 1 (CSRP1).