Cysteine and glycine-rich protein 3 (cardiac LIM protein) (CSRP3)

Cysteine and glycine-rich protein 3 (CSRP3), also referred to as cardiac LIM protein or muscle LIM protein, is a small structural protein (194 amino acids) encoded by the CSRP3 gene, predominantly expressed in cardiac and skeletal muscle. CSRP3 contains two LIM domains which mediate extensive protein–protein interactions with cytoskeletal, costameric, and nuclear factors, orchestrating sarcomeric organization, mechanical stretch sensing, and muscle differentiation. Mutations or altered expression of CSRP3 are directly linked to dilated and hypertrophic cardiomyopathy, as well as heart failure and various skeletal myopathies. CSRP3 serves as a scaffold essential for Z-disc integrity, actin filament stability, and mechanotransduction within myocytes, and also acts as a cofactor for transcription factors regulating myogenesis. Diagnostic and biomarker applications include detection of mutations or abnormal protein levels in cardiomyopathic tissues; however, direct pharmacological targeting and approved drugs for CSRP3 are currently absent

Other names

cardiac LIM proteinmuscle LIM proteinMLPCRP3CLPCMD1MCMH12LIM domain proteinLIM domain only 4cysteine-rich protein 3