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Target intelligence / Profile preview
Cysteine-rich hydrophobic domain-containing protein 1 (CHIC1)
- Target
- CHIC1
- Molecular classification
- Other (It is not classified as a receptor, enzyme, ion channel, transporter, transcription factor, or standard signaling molecule; it is a structural/membrane-associated protein[1][5][8].)
01
Overview
Cysteine-rich hydrophobic domain-containing protein 1 (CHIC1) is a membrane-associated protein encoded by the CHIC1 gene, one of the few protein-coding genes located near the X-inactivation center in humans and mice[1][5][7][8]. The protein contains a cysteine-rich hydrophobic (CHIC) domain, and mouse orthologs are subject to X-inactivation. CHIC1 is predicted to associate with membranes through post-translational palmitoylation of cysteine residues. While several transcript variants exist due to alternative splicing, the biological function of CHIC1 remains unclear, with no direct evidence supporting a role as a receptor, enzyme, or classical signaling molecule. There are genetic links with intellectual disability syndromes, but its molecular mechanism of involvement in disease is not established[1][5][7][8][9].
- Other names
- Cysteine-rich hydrophobic domain 1CHIC1Brain X-linked protein (BRX)brain X-linked proteincysteine-rich hydrophobic domain-containing protein 1BRX
02
Mechanism of action
None known (no drug mechanisms are described for this protein.)
03
Biological functions
Unknown/Unclear (As of current knowledge, there is no experimental evidence for a definitive molecular function or biological process involving CHIC1 in humans. Mouse studies suggest membrane association, possibly through palmitoylation, but specific cellular or physiological functions are not well-established[1][3][5][7].)
04
Disease associations
Non-syndromic X-linked intellectual disability 98Tonne-Kalscheuer syndromeOther (association is genetic and not well defined by functional or mechanistic studies; no strong evidence as a direct causal or therapeutic disease target[1].)
05
Safety considerations
None known (no safety, toxicity, or therapeutic challenges described.)
06
Interacting drugs
None known (no drugs are reported to interact with CHIC1[1][5][6].)
07
Biomarkers
None known (CHIC1 is not an established clinical biomarker.)
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