Cysteine-rich hydrophobic domain-containing protein 2 (CHIC2)

Cysteine-rich hydrophobic domain-containing protein 2 (CHIC2) is a small, palmitoylated membrane-associated protein found predominantly in vesicular structures and the plasma membrane. It belongs to the CHIC family and is characterized by a conserved cysteine-rich hydrophobic motif. While CHIC2 itself has not been shown to be a direct therapeutic target, its deletion in chromosome 4q12 serves as a critical diagnostic marker: it indicates the presence of the oncogenic FIP1L1–PDGFRA fusion in myeloproliferative neoplasms and mastocytosis, predicting response to tyrosine kinase inhibitors like imatinib. CHIC2 is also occasionally seen as a fusion partner with ETV6 in rare leukemia subtypes and may have other disease associations through its mRNA regulatory roles or gene dosage effects in glioblastoma and migraine. If you intend to retrieve structured target data for drug development or molecular pharmacology, CHIC2’s primary value is as a diagnostic biomarker and genetic marker for therapy selection, not as a classical drug target.

Other names

BTLBrX-like translocated in leukemiaCysteine-rich hydrophobic domain 2 proteinCysteine-Rich Hydrophobic Domain-Containing Protein 2Cystein-Rich Hydrophobic Domain 2

Not applicable for CHIC2 directly; for FIP1L1–PDGFRA, inhibition of tyrosine kinase activity (by imatinib)