Cysteine-rich transmembrane BMP regulator 1 (CRIM1)

**Cysteine-rich transmembrane BMP regulator 1 (CRIM1)** is a type I transmembrane protein that contains six cysteine-rich repeat (CRR) domains and an insulin-like growth factor (IGF)-binding domain[3][4][9]. CRIM1 modulates **bone morphogenetic protein (BMP)** activity by physically interacting with BMP4 and BMP7 within the Golgi compartment, thus altering their processing, cell-surface presentation, and secretion[1]. By controlling these processes, CRIM1 acts as an antagonist to BMPs, reducing their effective concentration in the microenvironment and contributing to tissue and organ development, particularly in the central nervous system, vasculature, and kidney[1][3][5][6][9]. Loss of function in animal models leads to significant developmental defects, especially in kidney and eye development, but CRIM1 is not currently known as a therapeutic target or associated with approved drugs[5].

Other names

Cysteine-rich motor neuron 1 proteinProcessed cysteine-rich motor neuron 1 proteinS52UNQ1886/PRO4330CRIM-1Cysteine-rich repeat-containing protein S52cysteine-rich repeat-containing protein S52cysteine-rich motor neuron 1 proteincysteine-rich transmembrane BMP regulator 1 (chordin-like)