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Target intelligence / Profile preview
Cystathionine Gamma Lyase (CGL)
- Target
- CGL
- Molecular classification
- Enzyme, Pyridoxal phosphate-dependent enzyme
01
Overview
Cystathionine gamma lyase (CGL) is a pyridoxal phosphate-dependent enzyme that catalyzes the breakdown of cystathionine into cysteine, α-ketobutyrate, and ammonia. It is the final enzyme in the trans-sulfuration pathway, converting methionine to cysteine. By generating hydrogen sulfide (H₂S), CGL participates in several physiological processes and has been implicated in cardiovascular diseases and cancer.
- Other names
- CTHCystathionaseCysteine synthase
02
Mechanism of action
Inhibition of CGL to modulate H₂S levels or activation of CGL to increase H₂S production.
03
Biological functions
Trans-sulfuration pathwayHydrogen sulfide (H₂S) productionVasodilationBone protectionInflammation modulationEndothelial function maintenanceExercise capacity enhancementCysteine biosynthesis
04
Disease associations
Cardiovascular diseaseCancerInflammation
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