Cysteinyl-leukotriene Receptor (CysLTR)

The cysteinyl-leukotriene receptors (CysLTRs) are G protein–coupled receptors (GPCRs) that mediate the biological effects of cysteinyl leukotrienes (CysLTs), which are lipid mediators derived from arachidonic acid metabolism. There are two main subtypes: CysLT1R and CysLT2R, both of which play significant roles in inflammatory processes. Activation of these receptors leads to airway bronchoconstriction, increased vascular permeability and edema, recruitment of eosinophils and neutrophils, smooth muscle proliferation and fibrosis, and mucin secretion, contributing to the pathogenesis of asthma, allergic rhinitis, cardiovascular diseases, and potentially other conditions like certain cancers and CNS disorders.

Other names

Cysteinyl Leukotriene ReceptorCysLT ReceptorLeukotriene Receptor

CysLT1 receptor antagonism