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Target intelligence / Profile preview
Cysteinyl Leukotriene Receptor 1 (CysLT1R)
- Target
- CysLT1R
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
Cysteinyl leukotriene receptor 1 (CysLT1R) is a G protein–coupled receptor (GPCR) that primarily mediates the biological effects of cysteinyl leukotrienes, which are lipid mediators derived from arachidonic acid metabolism. Activation of CysLT1R leads to airway bronchoconstriction, increased vascular permeability, recruitment of eosinophils and neutrophils, and other inflammatory responses. It is a key drug target for anti-asthmatic therapies.
- Other names
- CYSLTR1
02
Mechanism of action
Selective antagonism of the CysLT1 receptor, blocking the pro-inflammatory effects of cysteinyl leukotrienes.
03
Biological functions
Signal transductionBronchoconstrictionInflammationVascular permeabilityImmune response
04
Disease associations
AsthmaAllergic rhinitisInflammationBrain injuryMultiple sclerosisAlzheimer’s diseaseParkinson’s diseaseEpilepsy
05
Safety considerations
Efficacy varies among patientsPotential side effects associated with leukotriene receptor antagonists
06
Interacting drugs
Montelukast
2 more in the full profile.
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