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Target intelligence / Profile preview
Cysteinyl Leukotriene Receptor Type 1 (CysLT1R)
- Target
- CysLT1R
- Molecular classification
- G protein-coupled receptor
01
Overview
Cysteinyl leukotriene receptor type 1 is a key mediator linking lipid inflammatory signals to cellular responses central to allergy/asthma pathogenesis. Its pharmacological blockade forms a mainstay therapy for these conditions but with variable patient response profiles. Structurally distinct among GPCRs due to its unique disulfide bonding pattern between transmembrane domains—and functionally regulated by cytokines—it remains an active area for drug development targeting both respiratory diseases and broader inflammatory disorders.
02
Mechanism of action
Selective CysLT1R antagonism
03
Biological functions
Signal transductionAirway bronchoconstrictionIncreased vascular permeabilityEosinophil and neutrophil recruitmentSmooth muscle proliferationCollagen depositionMucin secretion
04
Disease associations
AsthmaAllergic rhinitisCardiovascular diseaseCancerInflammationFibrogranulomatous liver pathology
05
Safety considerations
Variable efficacy among patientsGastrointestinal symptomsNeuropsychiatric events
06
Interacting drugs
Montelukast
5 more in the full profile.
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