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Target intelligence / Profile preview
Cysteinyl-leukotriene type 1 receptor (CysLT1)
- Target
- CysLT1
- Molecular classification
- Leukotriene receptor, GPCR, G protein-coupled receptor
01
Overview
The cysteinyl-leukotriene type 1 receptor (CysLT1) is a G protein–coupled receptor (GPCR) that mediates the effects of cysteinyl leukotrienes. Primarily activated by leukotriene D4 (LTD4), it plays crucial roles in airway bronchoconstriction, increased vascular permeability, immune cell recruitment, and neuroinflammation. CysLT1 antagonists are used to treat asthma and allergic rhinitis.
- Other names
- CYSLTR1
02
Mechanism of action
Selective antagonists block CysLT1 receptor activation, preventing the pro-inflammatory and bronchoconstrictive effects of cysteinyl leukotrienes.
03
Biological functions
BronchoconstrictionVascular permeabilityImmune cell recruitmentSignal transductionAirway smooth muscle contractionMucin secretionLeukocyte migration into brain tissue
04
Disease associations
AsthmaAllergic rhinitisCardiovascular diseaseCancerInflammationBrain injury (trauma/ischemia)Multiple sclerosisAutoimmune encephalomyelitisAlzheimer’s diseaseParkinson’s disease
05
Safety considerations
Variable effectiveness among patients due to genetic polymorphisms or other factors.
06
Interacting drugs
Montelukast
5 more in the full profile.
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