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Target intelligence / Profile preview
Cystine-Glutamate Antiporter (System xc−)
- Target
- System xc−
- Molecular classification
- Transporter, Antiporter
01
Overview
The cystine-glutamate antiporter/system xc− plays essential roles in cellular antioxidant defense by importing cystine needed for GSH synthesis while simultaneously regulating extracellular glutamate concentrations—a process relevant not only under physiological conditions but also across diverse pathologies including cancer progression/resistance and neurological diseases characterized by altered redox states or excitatory signaling imbalances.
- Other names
- xCTSLC7A11/SLC3A2 heterodimer
02
Mechanism of action
Inhibition of cystine uptake and glutamate release
03
Biological functions
Amino acid transportRedox homeostasisGlutamate regulationGlutathione synthesis
04
Disease associations
CancerCentral Nervous System disordersEye DiseasesViral Pathology
05
Safety considerations
Potential for excitotoxicity due to altered glutamate levelsDisruption of redox balanceOff-target effects due to broad expression
06
Interacting drugs
Erastin
1 more in the full profile.
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