Target intelligence / Profile preview

Cytidine Deaminase (CDA)

Target: CDA
Molecular classification: Enzyme, Hydrolase, Aminohydrolase

Overview

Cytidine deaminase (CDA) is an enzyme that catalyzes the hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. This enzyme is crucial for maintaining cellular pyrimidine pools and salvaging nucleosides for nucleotide synthesis. CDA also inactivates certain chemotherapeutic agents, leading to drug resistance in cancer therapy.

Other names: CDDCytidine aminohydrolase

Mechanism of action

Hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine.

Biological functions

Pyrimidine salvage pathway maintenanceNucleotide metabolism

Disease associations

Cancer

Safety considerations

Drug resistance due to rapid drug degradation/inactivation

Interacting drugs

Ara-C (cytosine arabinoside)

1 more in the full profile.

Beyond the preview

Go deeper on Cytidine Deaminase (CDA).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Cytidine Deaminase (CDA).

Explore the full profile