Molecular Classification
Enzyme, Hydrolase, Aminohydrolase
Other Names
CDD, Cytidine aminohydrolase
Disease Roles
Cancer

Cytidine Deaminase Overview

Cytidine deaminase (CDA) is an enzyme that catalyzes the hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. This enzyme is crucial for maintaining cellular pyrimidine pools and salvaging nucleosides for nucleotide synthesis. CDA also inactivates certain chemotherapeutic agents, leading to drug resistance in cancer therapy.

Mechanism of Action

Hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine.

Biological Functions

Pyrimidine salvage pathway maintenance
Nucleotide metabolism

Disease Associations

Cancer

Safety Considerations

  • Drug resistance due to rapid drug degradation/inactivation

Interacting Drugs

Ara-C (cytosine arabinoside)
5-azacytidine